Data Sheet 1_National trends and county-level geographic disparities in mortality from ope

1999 to 2023 age-adjusted mortality data for operationally defined advanced cardiovascular–kidney–metabolic (CKM) stages from CDC WONDER death certificates. The dataset includes annual rates, trends, and state- and county-level mapping for stages 4 and 4b, authored by Kaide Xia and last updated in 2026. Overall mortality declined but reversed in the past decade, with a high-burden belt identified across the Deep South and Appalachia.

Use Cases

• Analyze long-term mortality trends for advanced CKM syndrome based on annual age-adjusted mortality rates from 1999 to 2023.
• Identify geographic hotspots and inequities in disease burden based on state- and county-level rate mapping for 2023.
• Study the relationship between cardiovascular disease and kidney failure based on the operational definitions of stage 4 and stage 4b.
• Assess spatial clustering patterns of mortality using derived metrics like the Stage 4b share within Stage 4.

Strengths

• Data spans 25 years (1999-2023), providing a long-term trend analysis.
• Includes detailed geographic analysis at both state and county levels for 2023.
• Uses an operational proxy definition for advanced CKM stages based on death certificate codes.
• Reports specific mortality rates, such as a decline from 505.54 to 353.30 per 100,000 for stage 4.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The 4.9 MB file size suggests a relatively small dataset, potentially limiting granularity.

Provenance

Source

CDC WONDER Multiple Cause of Death database.

Collection Method

Ecological time-series and spatial analysis of U.S. death certificate data.

Time Range

1999 to 2023

Freshness

Last updated 2026-05-29 04:47:30; freshness should be verified.

Geography

United States, with state- and county-level detail.