Neonatal DEHP Exposure Effects on Metabolic Outcomes in Male Rats

A figshare-hosted dataset by Thayná Martins Macario, last updated in June 2026, details an animal study on the endocrine-metabolic effects of di-(2-ethylhexyl) phthalate (DEHP). The study exposed lactating Wistar rats and their male offspring to DEHP at doses of 100 and 500 mg/kg/day, measuring outcomes at weaning (PND21) and adulthood (PND90). It likely contains tabular data on body weight, adiposity, serum hormone levels, and hypothalamic gene expression.

Use Cases

• Modeling dose-response relationships based on the described 100 mg/kg/day and 500 mg/kg/day exposure groups.
• Analyzing correlations between early-life adiposity changes and adult metabolic dysfunction based on described body weight and visceral white adipose tissue mass measurements.
• Investigating hypothalamic appetite control dysregulation based on described proopiomelanocortin (POMC) and neuropeptide Y (NPY) expression levels.
• Studying the Developmental Origins of Health and Disease (DOHaD) concept using the described neonatal exposure through breastfeeding model.

Strengths

• The study design includes two distinct exposure doses (100 and 500 mg/kg/day) and tracks outcomes at two life stages (weaning and adulthood).
• Specific biological endpoints are measured, including serum insulin, leptin, triiodothyronine (T3) levels, and hypothalamic gene expression.
• The dataset is openly shared under a CC-BY-4.0 license, facilitating reuse.

Limitations

• The dataset is small (78.1 KB), suggesting limited scope or summary-level data.
• Column-level documentation is absent; field semantics must be inferred from the PDF description.
• The sample size is limited, using 9 dams and 3 male pups per group for final analysis.

Provenance

Source

Thayná Martins Macario via figshare

Collection Method

Experimental study using Wistar rats; DEHP administered via oral gavage to dams during lactation.

Freshness

Last updated 2026-06-03 04:47:17