Data Sheet 1_Nerve growth factor responsive elements modulate immune cell inflammation and

A 1.4 MB PDF research article by Ruchi Gera, last updated April 23, 2026, under a CC-BY-4.0 license. The study maps nerve growth factor receptor expression across immune cell subtypes in mouse spleen using multi-color flow cytometry and single-cell RNA sequencing. It investigates receptor dysregulation in an Alzheimer's disease mouse model and the effect of NGF on inflammatory cytokine production.

Use Cases

• Study neuro-immune coupling mechanisms based on the mapping of NGF receptors (TrkA and p75) across immune cell types.
• Investigate inflammation resolution pathways based on the described effect of NGF supplementation on reducing cytokine production in T- and B-cells.
• Analyze age-dependent alterations in neurotrophin signaling based on findings from the Alzheimer's disease mouse model.
• Compare RNA and protein level expression discordance in immune cells based on the single-cell RNA sequencing results mentioned.

Strengths

• Data is derived from specific experimental methods: multi-color flow cytometry and single-cell RNA sequencing.
• Includes comparative analysis from an Alzheimer's disease mouse model, providing a disease context.
• Released under a permissive CC-BY-4.0 license, facilitating reuse.

Limitations

• The primary data file is a 1.4 MB PDF; underlying raw datasets (e.g., flow cytometry data, sequencing counts) are not directly provided.
• Row and column counts for any underlying tabular data are unknown, limiting suitability assessment for computational analysis.
• Column-level documentation is absent; field semantics must be inferred from the research article.

Provenance

Source

figshare

Collection Method

Multi-color flow cytometry and single-cell RNA sequencing of immune cells from unchallenged mouse spleen and an Alzheimer's disease mouse model.

Time Range

Experimental timeframe not specified.

Freshness

Last updated 2026-04-23 04:16:31; freshness should be verified.

Geography

Laboratory study; geographic origin not specified.