Neuroprotective Effects of Isoflavone-Enriched Soybean Leaves in a Mouse Model

A 2026 study by Young Ju Do investigating the neuroprotective and memory-enhancing effects of isoflavone-enriched soybean leaves (IESLs) on scopolamine-induced cognitive impairment in C57BL/6 mice. The dataset, a 130.8 KB document, details a 5-week experiment using Morris water maze and passive avoidance tests. Results indicate IESLs restored behavioral deficits dose-dependently via antioxidative mechanisms and activation of the CREB-BDNF pathway.

Use Cases

• Analyze dose-dependent neuroprotective effects based on behavioral test results described in the study.
• Investigate antioxidative defense mechanisms based on the described reduction of reactive oxygen species.
• Study signaling pathway activation based on the described upregulation of BDNF and CREB phosphorylation.
• Examine neuroinflammation attenuation based on the described suppression of astrocyte and microglia activation.

Strengths

• Detailed experimental methodology is described, including specific doses (6.25 and 18.8 mg/kg/day) and a 5-week duration.
• Mechanistic insights are provided, covering behavioral, biochemical, and histological analyses.
• Released under a permissive CC-BY-4.0 license.

Limitations

• The dataset is a 130.8 KB document; the underlying raw experimental data (e.g., columnar results) is not directly accessible.
• Row count and data structure are unknown, limiting suitability assessment for computational analysis.
• Column-level documentation is absent; field semantics must be inferred from the textual description.

Provenance

Source

Young Ju Do via figshare.

Collection Method

Experimental study involving oral administration of IESLs to C57BL/6 mice and behavioral/mechanistic testing.

Time Range

Study period not specified; document last updated in 2026.

Freshness

Last updated 2026-04-10 05:59:54.

Geography

Not specified.