NGF Administration Effects on GnRH Phenotype in Aging Mouse Hypothalamic NSCs

A research document describes experimental data on nerve growth factor (NGF) administration in aging male SAMP8 mice. The study measured serum hormone levels and evaluated GnRH immunoreactivity and neural stem cell differentiation. The document was authored by Jiao Luo and uploaded to figshare in April 2026.

Use Cases

• Analyze the relationship between NGF administration and serum hormone levels (LH, FSH, testosterone) based on time-series measurements mentioned in the description.
• Investigate GnRH-associated phenotypic changes in hypothalamic neural stem cells based on immunofluorescence and co-localization data described.
• Study signaling pathways involved in htNSC differentiation toward a neuroendocrine phenotype based on transcriptomic profiling and qPCR results mentioned.

Strengths

• The document provides a detailed methodological description of in vivo and in vitro experiments.
• The study includes multiple time points (8 h, 24 h, 96 h, 7 d, 10 d) for hormone level measurements.
• Experimental data includes both endocrine outputs and cellular phenotypic readouts.

Limitations

• The dataset is a 476.5 KB DOCX file, likely containing textual descriptions and figures rather than raw tabular data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Experimental study involving intracerebroventricular injections, hormone assays, immunofluorescence, and 3D cell culture.

Freshness

Last updated 2026-04-24 05:40:52; freshness should be verified.