Data Sheet 1: Niraparib, TM4SF1, and Ferroptosis in BRCA Wild-Type Ovarian Cancer

Data Sheet 1_Niraparib promotes ferroptosis by inhibiting TM4SF1 expression through ALKBH1-mediated 6mA modification in BRCA wild-type ovarian cancer.docx is a 936.1 KB document published on figshare under a CC-BY-4.0 license. The document, authored by Po-Wu Liu, details a study investigating the antitumor mechanisms of niraparib in BRCA wild-type ovarian cancer models, focusing on epigenetic regulation and ferroptosis. It was last updated on June 1, 2026.

Use Cases

• Studying the molecular mechanism of niraparib based on the described ALKBH1-mediated 6mA modification pathway.
• Investigating the role of TM4SF1 in ovarian cancer progression based on the described in vitro and in vivo assays.
• Analyzing the link between TM4SF1 inhibition and ferroptosis induction based on the described Fe2+ and lipid ROS measurements.
• Exploring epigenetic regulation in BRCA wild-type ovarian cancer treatment based on the described 6mA modification findings.

Strengths

• The study description is detailed, outlining specific experimental methods like 6mA-IP-seq, RT-qPCR, and in vivo xenograft models.
• The document is openly licensed (CC-BY-4.0), allowing for reuse and distribution.
• The research focuses on a clinically relevant problem: improving treatment for BRCA wild-type ovarian cancer.

Limitations

• The dataset is a single 936.1 KB DOCX file, which suggests a limited scope, likely containing summary data, figures, and text rather than raw, large-scale datasets.
• Row count and column-level documentation are absent, making it difficult to assess the structure and granularity of any underlying data.
• The data may reflect the specific experimental models and conditions of the study, limiting generalizability.

Provenance

Source

Po-Wu Liu via figshare.

Collection Method

Likely contains experimental data and analysis from laboratory studies on ovarian cancer models, as described in the methods section.

Freshness

Last updated 2026-06-01 07:43:59; freshness should be verified.