Data Sheet 1: NOX2-Mediated Ferroptosis in Periodontitis

A 9.9 MB document by Yuan Ping, last updated March 2026, containing data and analysis on the role of NOX2 in periodontitis. The study includes in vitro results from Pg-LPS-stimulated CA9–22 gingival epithelial cells and in vivo results from a C57BL/6 mouse model. Measurements include protein expression levels, malondialdehyde (MDA) for lipid peroxidation, and reactive oxygen species (ROS) detection.

Use Cases

• Analyze the relationship between NOX2 expression and ferroptosis markers like GPX4 and SLC7A11 based on Western blot data.
• Investigate the link between reactive oxygen species (ROS) levels and alveolar bone loss based on micro-CT and staining results.
• Study the activation of the TLR4/NF-κB and JAK2-STAT3 pathways in response to Pg-LPS stimulation.
• Validate in vitro findings of NOX2 gene silencing with in vivo results from pharmacological inhibition in a mouse model.

Strengths

• Data is associated with a specific, peer-reviewed research hypothesis on NOX2 and ferroptosis.
• Includes results from both in vitro (CA9–22 cell line) and in vivo (C57BL/6 mouse) experimental models.
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• The 9.9 MB size suggests a small dataset, likely a supplementary document rather than a primary data repository.
• Row count and column-level documentation are absent; field semantics must be inferred after download.
• Data may reflect experimental bias inherent to the specific cell line and mouse model used.

Provenance

Source

Yuan Ping via figshare.

Collection Method

Experimental data from Western blotting, micro-CT analysis, H&E/TRAP staining, and spectrophotometry on cell cultures and mouse tissues.

Freshness

Last updated 2026-03-18 07:38:19; freshness should be verified.