NRF2 Gene Expression and Clinical Data from a Heat Stroke Patient Study, 2023-2025

Clinical and transcriptomic data from a prospective study of 49 heat stroke patients and healthy volunteers conducted from January 2023 to June 2025. The dataset includes demographic characteristics, vital signs, disease-severity scores (APACHE II, SOFA), laboratory parameters, and outcome measures. It was authored by Guodong Lin and shared under a CC-BY-4.0 license.

Use Cases

• Correlating NRF2 and NQO1 gene expression levels with disease severity scores (APACHE II, SOFA) to identify potential biomarkers.
• Analyzing relationships between oxidative stress markers (malondialdehyde, protein carbonyl) and inflammatory markers (interleukin-6, C-reactive protein) in severe vs. mild heat stroke.
• Modeling patient outcomes (length of hospitalization) based on combinations of laboratory parameters and vital signs.
• Comparing transcriptomic profiles between patient groups (severe heat stroke, mild heat stroke, healthy controls) to understand pathogenic mechanisms.

Strengths

• Includes 49 patient records with detailed clinical and laboratory measurements.
• Contains transcriptomic analysis data for NRF2 and its downstream gene NQO1.
• Prospective study design with data collected from January 2023 to June 2025.
• Dataset is openly shared under a permissive CC-BY-4.0 license.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data may reflect geographic bias inherent to the single hospital source (General Hospital of the Southern Theater Command of the Chinese People’s Liberation Army).

Provenance

Source

figshare, authored by Guodong Lin.

Collection Method

Prospective clinical study with data collection including demographics, vital signs, lab tests, and transcriptomic analysis.

Time Range

January 2023 to June 2025.

Freshness

Last updated 2026-04-16 05:24:07; freshness should be verified.

Geography

General Hospital of the Southern Theater Command of the Chinese People’s Liberation Army (China).