Research Paper on Oleic Acid and Alzheimer's Disease Pathology in Mouse Models

A 176.2 KB PDF research paper by YiBo Xie, last updated in April 2026, investigates the role of oleic acid in Alzheimer's disease. The study combines NHANES survey data analysis with experimental validation in APP/PS1 mouse and astrocyte cell models. It concludes that oleic acid ameliorates pathology via the PKA/ACACB/CPT1A pathway to restore astrocytic fatty acid oxidation.

Use Cases

• Analyzing the association between monounsaturated fatty acid intake and cognitive function based on NHANES survey data mentioned in the description
• Studying gene expression patterns related to fatty acid metabolism dysregulation in Alzheimer's disease based on referenced GEO datasets
• Validating the effects of dietary oleic acid supplementation on amyloid plaque deposition and cognitive performance in mouse models
• Investigating the PKA/ACACB/CPT1A signaling pathway in astrocyte injury models based on the described cellular assays

Strengths

• The dataset is a published research paper with a clear CC-BY-4.0 license for reuse.
• The study design integrates human epidemiological data (NHANES 2011-2014) with experimental models (mouse and cell).

Limitations

• The primary data file is a 176.2 KB PDF, which is a text document, not a structured dataset for direct computational analysis.
• Row count and column-level documentation are unknown, limiting suitability assessment for ML tasks.
• Description metadata is limited; actual underlying experimental data quality requires manual inspection after download.

Provenance

Source

figshare, author YiBo Xie

Collection Method

Research combining analysis of public datasets (NHANES, GEO) with original experimental work.

Time Range

NHANES data from 2011-2014; experimental work timeframe not specified.

Freshness

Last updated 2026-04-15 05:43:57; freshness should be verified.

Geography

Not explicitly stated, but NHANES data is U.S.-based.