PM2.5 and Thyroid Hormone Levels in a Preconception Cohort in Liaoning, China

1,357 women planning pregnancy were included in a cohort study conducted in Liaoning, China between January 2019 and December 2023. The data shows opposing effects of PM2.5 exposure on thyroid-stimulating hormone levels, depending on thyroid autoimmunity status. This dataset, authored by Heze Xu and shared under a CC-BY-4.0 license, is a 478.7 KB document analyzing effect modification by thyroid peroxidase antibodies.

Use Cases

• Modeling the interaction between environmental exposure and autoimmune status on hormone levels based on the described effect modification analysis.
• Investigating time-window sensitivity of air pollution exposure based on the 1 to 12 month exposure periods estimated prior to blood draw.
• Training models to identify susceptible populations for environmental health interventions based on the TPOAb-positive subgroup identified in the results.

Strengths

• Includes data from 1,357 participants, providing a substantive cohort size for analysis.
• Contains multiple measured biomarkers: serum TSH, FT4, FT3, TPOAb, and TgAb status.
• PM2.5 exposure was estimated for specific time windows (1 to 12 months), allowing for temporal analysis.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for certain modeling tasks.
• The dataset is small (478.7 KB), indicating limited scope, likely containing summary results rather than raw individual-level data.

Provenance

Source

Part of the China Medical University Birth Cohort study.

Collection Method

Cohort study with serum measurements and estimated PM2.5 exposure, analyzed using linear regression with interaction terms.

Time Range

Data collection occurred between January 2019 and December 2023.

Freshness

Last updated 2026-06-02 04:28:26; freshness should be verified.

Geography

Liaoning, China.