Data Sheet 1_Optimal strategies for umbilical cord mesenchymal stem cell–derived exosomes

A 2026 document by Pingping Wanyan presents a systematic review and meta-analysis of 14 preclinical studies. It synthesizes evidence on the efficacy of umbilical cord mesenchymal stem cell-derived exosomes for treating acute kidney injury in rat models. The analysis compares outcomes like serum creatinine and blood urea nitrogen across different administration routes and doses.

Use Cases

• Comparing the efficacy of tail vein versus subcapsular renal injection based on the network meta-analysis results
• Analyzing dose-response relationships for exosome therapies based on the described patterns for 30μg to 400μg doses
• Evaluating treatment effects on renal function markers like serum creatinine and blood urea nitrogen based on the pooled effect sizes

Strengths

• The analysis is based on 14 included randomized controlled studies, providing a quantitative synthesis.
• Effect sizes are reported with specific standardized mean difference values and confidence intervals, such as SMD = -5.60 for serum creatinine.
• The network meta-analysis provides comparative rankings (SUCRA scores) for different intervention strategies.

Limitations

• The underlying raw data from the 14 studies is not provided; the document contains only the analysis results.
• Methodological reporting quality of the included studies is described as generally inadequate.
• Potential publication bias was detected, though the adjusted effect size remained significant.

Provenance

Source

figshare, author Pingping Wanyan.

Collection Method

Systematic literature search of PubMed, Web of Science, Embase, and Scopus, followed by conventional and network meta-analyses.

Freshness

Last updated 2026-04-28.