Zika Virus Polymerase Assay Data with 204 Natural Product Screenings

204 compounds from the Natural Product Set IV of the National Cancer Institute Developmental Therapeutics Program were screened for activity against the Zika virus RNA-dependent RNA polymerase. The dataset, authored by Vanessa Aitken and last updated in April 2026, contains results from an optimized malachite green colorimetric assay. It identifies two preliminary modulator compounds, purpurogallin and digallic acid.

Use Cases

• Screening for antiviral compounds based on enzyme inhibition data.
• Validating biochemical assay protocols for viral polymerases.
• Comparing natural product libraries for drug discovery against Zika virus.
• Training ML models to predict compound activity from screening results.

Strengths

• Contains results for a specific screen of 204 natural product compounds.
• Focuses on a validated biochemical assay (malachite green colorimetric) for a key viral enzyme.
• Identifies two preliminary hit compounds (purpurogallin and digallic acid) for further study.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data is contained in a PDF file (529.1 KB), which may require extraction for computational analysis.

Provenance

Source

figshare, authored by Vanessa Aitken.

Collection Method

Experimental data from a biochemical enzyme assay optimization and screening study.

Time Range

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Freshness

Last updated 2026-04-14 11:48:04

Geography

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