Ovarian Endometrioid Carcinoma Case Report with Genomic and Transcriptomic Data

Shanshan Guo published a case report on figshare in 2026 detailing a rare ovarian cancer variant. The report includes genomic and transcriptomic analyses from a single 71-year-old patient diagnosed with low-grade ovarian endometrioid carcinoma with sex cord-like features. It describes findings from hematoxylin and eosin staining, immunohistochemistry, molecular subtyping, and transcriptomic sequencing.

Use Cases

• Study the molecular profile of a rare ovarian cancer variant based on the described genomic and transcriptomic analyses.
• Analyze the role of the WNT pathway as an oncogenic driver in endometrioid carcinoma based on the transcriptomic profiling mentioned.
• Investigate the relationship between CTNNB1 mutations and tumor morphology based on the identified p.D32Y missense mutation.
• Compare transcriptomic signatures of endometrioid carcinoma with sex cord-like features to other ovarian tumors based on the pathway enrichment results described.

Strengths

• Includes detailed molecular profiling (genomic and transcriptomic sequencing) for a rare tumor type.
• Case report provides specific immunohistochemistry results (positivity for epithelial markers, negativity for sex cord markers).
• Identifies a specific CTNNB1 mutation (p.D32Y in exon 3) and dominant pathway activity (WNT).
• Published under a permissive CC-BY-4.0 license for reuse.

Limitations

• Dataset is a 72.0 KB DOC file, indicating a limited textual case report rather than a large-scale data collection.
• Row count and column definitions are unknown, limiting structured data analysis.
• Data is from a single patient case, which limits generalizability and statistical power.

Provenance

Source

figshare, author Shanshan Guo.

Collection Method

Clinical case study with comprehensive staging surgery, histopathologic assessment, immunohistochemistry, molecular subtyping, and transcriptomic sequencing.

Freshness

Last updated 2026-05-29 04:48:56.