Oxidative Stress Response of Yeast Exposed to Polycyclic Aromatic Hydrocarbons

A dataset from a study investigating the toxic effects of different molecular weight polycyclic aromatic hydrocarbons (PAHs) on the model organism Saccharomyces cerevisiae. The research assessed oxidative stress biomarkers including gene expression, reactive oxygen species generation, superoxide dismutase activity, and glutathione content after 24-hour exposure to phenanthrene, fluoranthene, benzo[ghi]perylene, and benzo[a]pyrene. The results demonstrated that cell viability and toxicity levels were related to PAH molecular weight and benzene ring count.

Use Cases

• Modeling oxidative stress response based on gene expression data for SOD1 and SOD2.
• Analyzing toxicity levels based on molecular weight and benzene ring count of PAHs.
• Correlating reactive oxygen species formation with superoxide dismutase activity.
• Investigating glutathione level changes as a biomarker of PAH exposure.

Strengths

• Data includes results for four specific PAHs (phenanthrene, fluoranthene, benzo[ghi]perylene, benzo[a]pyrene).
• Multiple oxidative stress endpoints were assessed: gene expression, ROS, SOD activity, and glutathione content.
• Uses a standard eukaryotic model organism (Saccharomyces cerevisiae).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (319.5 KB), indicating limited scope.

Provenance

Source

Pennapa Takam via figshare

Collection Method

Experimental study exposing yeast cells to PAHs for 24 hours and measuring oxidative stress biomarkers.

Freshness

Last updated 2026-05-25 06:03:33; freshness should be verified.