Data Sheet 1_Panax ginseng—Polygonum cuspidatum is beneficial for alleviating atherosclerosis in ApoE−/− mice by modulating the composition of gut microbiota and related metabolites.pdf

Sixty ApoE−/− mice were used to study the effects of a Panax ginseng and Polygonum cuspidatum herb pair on atherosclerosis, gut microbiota, and metabolites. The dataset includes measurements of aortic plaque burden, serum lipid levels, inflammatory cytokines, metagenomic sequencing data, and untargeted metabolomics results from a 12-week intervention study. Author Ya Wang published the supporting data in April 2026 under a CC-BY-4.0 license.

Use Cases

• Identify differential gut microbiota taxa (e.g., Bifidobacteriales, Bacteroidetes, Escherichia coli) associated with atherosclerotic plaque reduction.
• Correlate changes in serum lipid metrics (TC, TG, LDL-C) and inflammatory cytokines (MCP-1, MCP-3, IL-2) with specific metabolite levels like 1-methylnicotinamide.
• Analyze the relationship between intestinal barrier integrity markers (ZO-1, Occludin expression, goblet cell count) and fecal microbiota transplantation outcomes.
• Model the dose-response effect of the herbal intervention using data from low, medium, and high-dose GP groups compared to statin and model controls.

Strengths

• Data from a controlled animal study with 60 mice across 5 intervention groups and a control group.
• Includes multi-omics measurements: metagenomic sequencing for gut microbiota and untargeted metabolomics for 22 identified metabolites.

Limitations

• Small sample size of 60 mice limits statistical power for detecting subtle effects or rare microbial taxa.
• Data is derived from a single, highly specific mouse model (HFD-induced ApoE−/−), limiting generalizability to other species or disease states.

Provenance

Source

figshare, uploaded by author Ya Wang.

Collection Method

Generated from a preclinical mouse study involving dietary intervention, tissue staining, serum assays, DNA sequencing, and mass spectrometry.

Time Range

Covers a 12-week experimental intervention period.

Freshness

Data was last updated in April 2026, representing recent research.

Geography

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