Pathogenicity of P. gingivalis Strains with Specific Polymorphic Variants of the PPAD Gene

35 periodontitis patient and 20 healthy donor isolates reveal three predominant clusters of polymorphic variants in the P. gingivalis ppad gene. Infection with strains carrying the S203P + G231N, E232T, N235D + N291D + A515V + S528G variant cluster led to a 94% reduction in the bone resorption marker OPG and significant upregulation of inflammatory cytokines. This dataset, authored by Karolina Strzelec and last updated in May 2026, links specific genetic variants to enzymatic function and disease severity.

Use Cases

• Correlating specific ppad gene variant clusters with clinical disease severity indicators mentioned in the description
• Modeling the relationship between PPAD enzymatic activity and host inflammatory cytokine expression (e.g., IL-1b, TNF-α)
• Analyzing genetic variability of a key bacterial virulence gene across patient and healthy control cohorts

Strengths

• Data is derived from a defined clinical cohort of 35 periodontitis patients and 20 healthy donors
• Findings link specific variant clusters to concrete biological outcomes, such as a 94% reduction in OPG and 6-7 fold increases in cytokine expression
• Dataset is openly shared under a CC-BY-4.0 license

Limitations

• The dataset is very small at 143.0 KB, indicating limited scope
• Row count and column-level documentation are unknown, requiring manual inspection after download
• The description is detailed but the underlying data file format is a DOC document, which may complicate direct analysis

Provenance

Source

figshare

Collection Method

Clinical isolates from gingival crevicular fluid were analyzed using PCR, BLAST, qRT-PCR, and colorimetric assays

Freshness

Last updated 2026-05-12 05:42:19