Cochlear Ribbon Synapse Development Data from Optogenetic Experiments

This dataset supports a study on activity-dependent structural plasticity in developing cochlear ribbon synapses. It includes data from genetic, pharmacological, and optogenetic experiments, including results from a novel optical stimulation device. The research investigates how pre-sensory spontaneous activity shapes synaptic morphology prior to hearing onset.

Use Cases

• Analyze the relationship between optogenetic activation patterns and subsequent changes in ribbon synapse morphology.
• Compare synaptic structural refinements resulting from genetic versus pharmacological activity modulation approaches.
• Investigate the temporal dynamics of homeostatic scaling in cochlear inner hair cells using immunohistochemical data.
• Correlate electrophysiological analysis results with observed structural changes in the auditory system.

Strengths

• Data is derived from a multi-method experimental framework combining genetic, pharmacological, and optogenetic approaches.
• Includes results from a novel optical stimulation device enabling millisecond-precise, long-term optogenetic activation.
• Study is published under the open CC BY 4.0 license, facilitating reuse and verification.

Limitations

• The dataset is a single 2.8 MB PDF file, which is a small-scale publication rather than a large, structured data repository.
• Raw experimental data, column definitions, and sample data are unavailable, limiting direct computational analysis.
• The focus is on a specific developmental period in the mammalian cochlea, limiting generalizability to other systems or timeframes.

Provenance

Source

figshare, authored by Victoria C. Halim.

Collection Method

Combined genetic, pharmacological, and optogenetic approaches with immunohistochemical and electrophysiological analyses.

Time Range

Covers the early postnatal maturation period prior to hearing onset.

Freshness

Last updated on 2026-03-23.

Geography

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