Perinatal Cholinergic Activation Effects on Cortical Basket Cell Differentiation

A research article by Petra Wahle, last updated May 14, 2026, details experimental findings on cortical circuit development. The study explores how mAChR-mediated activation of subplate neurons in early postnatal neocortex triggers network activity that influences the maturation of basket cells. Results are based on ex vivo stimulation and organotypic cortex culture experiments measuring protein expression and calcium event frequency.

Use Cases

• Modeling the role of cholinergic input in cortical circuit development based on described protein expression changes.
• Analyzing the timeline of basket cell morphological maturation based on repeated stimulation experiments from DIV 1-5 to DIV 15.
• Studying the link between glutamatergic network activity and inhibitory synapse development based on reported increases in VGAT and synaptotagmin-2 expression.

Strengths

• The description provides detailed experimental methodology and specific protein targets measured.
• The dataset is openly licensed under CC-BY-4.0.

Limitations

• The dataset is a 751.2 KB PDF file, not a structured data table; column-level documentation is absent.
• Row count is unknown, which may limit suitability assessment.
• Freshness should be verified as the last update date is in the future (2026-05-14).

Provenance

Source

Petra Wahle via figshare

Collection Method

Experimental data from ex vivo stimulation and organotypic cortex cultures of visual and somatosensory cortex.

Freshness

Last updated 2026-05-14 04:29:31