ABCD1 Deficiency Mouse Study: Th1 Bias in CD4+ T Cells

A 388.3 KB PDF published on figshare in May 2026 by Reina Maeda investigates the immunometabolic link between peroxisomal lipid metabolism and T cell differentiation. The study defines a 25-HC–LXR–Blimp-1 axis as a mechanistic link regulating CD4+ T−cell polarization in Abcd1-deficient mice, with potential relevance to X-linked adrenoleukodystrophy (X-ALD)–associated neuroinflammation.

Use Cases

• Analyze transcriptional profiles of Abcd1-deficient CD4+ T cells based on the description of Ifng, Tbx21, and Prdm1 expression.
• Investigate the role of oxysterol 25-hydroxycholesterol (25-HC) in T cell polarization based on the described Ch25h upregulation.
• Model the effects of LXR agonist T0901317 and antagonist SR9238 on Blimp-1 and IL-10 restoration based on the pharmacological modulation described.
• Study the link between peroxisomal ABCD1 dysfunction and Th1 bias in a mouse model of X-linked adrenoleukodystrophy.

Strengths

• The dataset is licensed under CC-BY-4.0, allowing for open sharing and reuse.
• The description provides a detailed mechanistic pathway involving Ch25h, 25-HC, LXR, and Blimp-1.

Limitations

• The dataset is a single 388.3 KB PDF file, which suggests a limited scope of raw data.
• Column-level documentation is absent; field semantics must be inferred from the text.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.

Provenance

Source

figshare

Collection Method

Likely contains experimental data from mouse models and in vitro assays as described.

Freshness

Last updated 2026-05-20 05:50:17; freshness should be verified.