Pharmacogenomics of Direct Oral Anticoagulants: Systematic Review and Meta-Analysis

39 studies involving 13,300 patients were included in this systematic review and meta-analysis investigating genetic influences on direct oral anticoagulants. The study, authored by Huaru Chai and published on figshare in April 2026, identified associations between polymorphisms in genes like CES1, ABCB1, and SLCO1B1 and variability in drug pharmacokinetics and bleeding risk. It concludes that current evidence is insufficient for genotype-guided dosing in clinical practice.

Use Cases

• Training models to predict drug exposure variability based on genetic polymorphisms like CES1 rs2244613.
• Analyzing associations between ABCB1 genotypes and bleeding risk outcomes for rivaroxaban.
• Meta-analysis of pharmacogenomic study results to validate findings on gene-drug interactions.

Strengths

• Includes data from 39 studies with a total of 13,300 patients.
• Meta-analysis was performed on results with 3 or more studies, providing aggregated evidence.
• Published under a CC-BY-4.0 license, allowing for reuse and redistribution.

Limitations

• The primary data file is a 4.5 MB PDF; underlying tabular data from the meta-analysis is not directly provided.
• Row count and column-level documentation for any underlying data are unknown.
• The description notes heterogeneity and limited sample sizes in the included studies as a limitation of the evidence.

Provenance

Source

figshare, author Huaru Chai.

Collection Method

Systematic review and meta-analysis of studies from PubMed, Embase, Web of Science, and Cochrane Library up to October 29, 2025.

Time Range

Studies included up to October 29, 2025.

Freshness

Last updated 2026-04-14 04:21:36.