PHGDH-Mediated Serine Synthesis in Oligodendrocyte Survival After Brain Ischemia

Data Sheet 1_PHGDH-mediated serine synthesis reduces oligodendrocyte death by sustaining GSH and NADPH levels after brain ischemia.pdf is a 404.5 KB PDF file published on figshare by Zhaolong Zhang under a CC-BY-4.0 license. The document contains research data and results from a study investigating the role of the PHGDH enzyme in protecting oligodendrocytes from ischemic injury. The dataset was last updated on 2026-04-15.

Use Cases

• Analyze the relationship between PHGDH expression and oligodendrocyte survival based on immunofluorescence staining data.
• Model the impact of serine synthesis on glutathione (GSH) and NADPH levels based on mechanistic pathway descriptions.
• Correlate PHGDH inhibition with sensorimotor and cognitive functional outcomes based on neurobehavioral assessment data.
• Investigate reactive oxygen species (ROS) levels in oligodendrocytes under ischemic conditions based on flow cytometry analysis.

Strengths

• Dataset is openly available under a permissive CC-BY-4.0 license.
• File size is 404.5 KB, indicating a focused and manageable document for analysis.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The data is contained within a PDF, which may require extraction for computational analysis.

Provenance

Source

Zhaolong Zhang via figshare.

Collection Method

Data appears to be generated from laboratory experiments involving transient middle cerebral artery occlusion, immunofluorescence, CCK8 assays, and flow cytometry.

Time Range

Experimental timeframe is not specified.

Freshness

Last updated 2026-04-15 05:32:44; freshness should be verified.

Geography

Geographic scope of the study is not specified.