PhIP-Driven Prostate Cancer: Molecular Regulators and Immune Microenvironment

Data Sheet 1_PhIP-driven prostate cancer involves key molecular regulators and immune microenvironment modulation.docx is a 1.6 MB document authored by Yaoan Wen and last updated on April 10, 2026. It details a study identifying 17 candidate genes associated with prostate cancer induced by the chemical PhIP, with SLC14A1 highlighted as a dominant contributor. The research integrates network toxicology, bioinformatics, and machine learning, validated by molecular simulations and experiments.

Use Cases

• Identify potential molecular biomarkers for PhIP-induced prostate cancer based on the 17 candidate genes.
• Analyze the association between SLC14A1 expression and the tumor immune microenvironment based on immune infiltration analysis.
• Validate molecular docking predictions for PhIP-protein interactions based on simulation results.
• Investigate epithelial localization patterns of key genes in prostate cancer based on single-cell analysis.

Strengths

• Identifies 17 candidate genes associated with PhIP-induced prostate cancer.
• Integrates multiple analytical methods including machine learning, molecular docking, and experimental validation.
• Released under a CC-BY-4.0 license, permitting open reuse.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is a 1.6 MB DOCX file, which may limit direct computational analysis without text extraction.

Provenance

Source

Yaoan Wen via figshare.

Collection Method

Generated by integrating network toxicology, bioinformatics, and machine learning algorithms, with experimental validation.

Time Range

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Freshness

Last updated 2026-04-10 05:29:08; freshness should be verified.

Geography

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