PIKfyve Role in Mycobacterial Vesicle Maturation: Zebrafish Infection Study

A 3.7 MB PDF research article authored by Salomé Muñoz-Sánchez and last updated on 2026-04-15. The study investigates the role of the phosphoinositide kinase PIKfyve in the immune defense against Mycobacterium marinum infection in zebrafish larvae. It examines how PIKfyve facilitates autophagy pathway activation and vesicle trafficking towards degradative lysosomes in infected macrophages.

Use Cases

• Analyzing the role of PIKfyve in autophagosome maturation based on the described chemical inhibitor studies.
• Studying host immune response mechanisms against mycobacterial infection based on the described cell death and trafficking observations.
• Investigating phosphoinositide signaling in pathogen degradation pathways based on the described PtdIns(3,5)P2 generation.

Strengths

• File size is 3.7 MB, indicating a manageable download.
• License is CC-BY-4.0, permitting broad reuse and adaptation.
• Last updated date is explicitly provided (2026-04-15).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The primary data format is a PDF, which may require extraction for computational analysis.

Provenance

Source

figshare

Collection Method

Likely contains experimental data from a study using zebrafish larvae and macrophage infection models with chemical inhibitors.

Time Range

The study's temporal coverage is not specified in the provided metadata.

Freshness

Last updated 2026-04-15 05:44:14; freshness should be verified.

Geography

The geographic scope of the data collection is not specified.