Porcine ARDS Model Intracranial Pressure Response to PEEP

A study of 12 anesthetized pigs with induced ARDS investigates the effects of stepwise PEEP increases on intracranial physiology. It analyzes continuous measurements of intracranial pressure (ICP), pressure reactivity index (PRx), and brain tissue oxygenation (PbO2) across prone and supine positions. The dataset is a 113.1 KB document detailing the experimental methods and results.

Use Cases

• Analyze the relationship between PEEP level and ICP changes using the provided experimental data
• Compare PRx stability across different body positions (prone vs. supine) described in the study
• Investigate the association between baseline physiological variables like pulmonary artery pressure and the magnitude of ICP response
• Examine trends in PbO2 and the PbO2/PaO2 ratio relative to PEEP escalation

Strengths

• Data originates from a controlled, randomized crossover experiment with 12 subjects
• Study includes continuous monitoring of key cerebral variables: ICP, PRx, and PbO2
• Dataset is openly shared under a CC BY 4.0 license

Limitations

• The dataset is a 113.1 KB document, not a structured tabular dataset, limiting direct computational analysis
• Sample size is small with only 12 animal subjects, limiting statistical power
• Data is specific to a porcine model and may not directly translate to human physiology

Provenance

Source

Figshare, authored by Rønnaug Hammervold

Collection Method

Experimental data from a porcine ARDS model using bronchial lavage, with stepwise PEEP manipulation in prone and supine positions

Freshness

Last updated on 2026-03-25.