Data Sheet 1_Potential efficacy and preliminary mechanistic insights of the Jianpi Yishen

Weidong Liang's pilot study data explores the efficacy of the Jianpi Yishen Zhuanggu Tongluo formula for rheumatoid arthritis with sarcopenia-osteopenia. The dataset includes clinical outcomes for 40 patients over 12 months, covering inflammatory markers, bone density, muscle mass, and metabolomics results. The data was uploaded to figshare on April 21, 2026, under a CC-BY-4.0 license.

Use Cases

• Compare treatment efficacy based on clinical metrics like DAS28-ESR, BMD, and ASMI mentioned in the description.
• Analyze correlations between inflammatory markers (CRP, ESR, TNF-α) and bone metabolism markers (CTX, PINP).
• Investigate preliminary metabolic biomarker alterations in glucose, lipid, and amino acid pathways identified via 1H-NMR metabolomics.
• Study potential mechanistic pathways like PINK1/PARKIN and OPG/RANK suggested by in vitro experiment results.

Strengths

• Includes data from a randomized clinical pilot study with 40 patients.
• Covers 12 months of treatment and tracks multiple clinical outcome domains (inflammatory, bone, muscle, metabolic).
• Dataset is openly licensed under CC-BY-4.0.

Limitations

• Row count and column-level documentation are unknown, which may limit suitability assessment.
• The dataset is small (114.3 KB), indicating limited scope and sample size.
• Description metadata is limited; actual data quality and structure require manual inspection after download.

Provenance

Source

Weidong Liang via figshare.

Collection Method

Data collected from a randomized clinical pilot study (ChiCTR2500106729) involving 40 patients.

Time Range

Study duration was 12 months; specific years are not provided.

Freshness

Last updated 2026-04-21 05:36:10; freshness should be verified.