Precuneus Hyperexcitability in Sleep Disruption and Pain: Neuroimaging and Cytokine Data

A multimodal neuroimaging study by Chao Li, last updated in May 2026, investigates the link between sleep disruption, inflammation, and pain hypersensitivity. The dataset includes results from an experimental forced-awakening study and a longitudinal chronic pain patient cohort, incorporating polysomnography, task-fMRI, structural MRI, inflammatory cytokine (IL-6) measurements, and quantitative sensory testing. It identifies the precuneus as a cortical hub mediating neuroimmune-pain interactions.

Use Cases

• Training models to predict pain thresholds based on neuroimaging features and cytokine levels mentioned in the description
• Analyzing brain region hyperactivation patterns, such as in the precuneus and middle temporal gyrus, during pain processing
• Building mediation models to test the relationship between inflammatory markers, brain activity, and clinical pain metrics
• Correlating longitudinal changes in brain normalization with improvements in sleep quality and pain scores

Strengths

• Multimodal data integration combining neuroimaging, polysomnography, cytokine assays, and sensory testing
• Complementary experimental and longitudinal clinical cohort designs described in the methodology
• Clear mechanistic findings, such as the mediating role of precuneus hyperexcitability on the IL-6-pain relationship

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The primary file is a 309.1 KB DOCX document, suggesting the dataset is small and likely contains summarized results rather than raw data tables

Provenance

Source

figshare

Collection Method

Experimental forced-awakening study and longitudinal assessment of chronic pain patients using neuroimaging and clinical metrics.

Time Range

The longitudinal cohort was assessed pre- and 3-months postoperatively.

Freshness

Last updated 2026-05-04 04:18:12

Geography

Geography is not specified in the provided input.