Prefrontal and Hippocampal Gray Matter Microstructure Data from Hypoxia-Cognition Trial

A clinical trial dataset investigates gray matter microstructure changes following cognitive training under moderate hypoxia in individuals with remitted mood disorders. The data includes diffusion-weighted MRI scans and cognitive test results for 57 participants assessed at baseline and 8 weeks. Author Kristian H. R. Jensen published the data sheet in April 2026.

Use Cases

• Analyze associations between Neurite Density Index (NDI) and cognitive test scores for executive function.
• Compare baseline Orientation Dispersion Index (ODI) values in the prefrontal cortex between treatment and control groups.
• Model longitudinal changes in hippocampal microstructure metrics from baseline to the 8-week follow-up.
• Investigate correlations between demographic features like age and gender with baseline gray matter microstructure.

Strengths

• Includes data from 57 participants with baseline MRI assessments.
• Provides paired measurements at baseline and an 8-week follow-up time point.

Limitations

• The dataset is described in a single document file (527.4 KB), limiting direct computational analysis.
• No significant microstructural changes were detected in the primary trial analysis, limiting predictive modeling potential.
• Sample size of 57 participants may be insufficient for detecting subtle neuroimaging effects.

Provenance

Source

figshare, authored by Kristian H. R. Jensen.

Collection Method

Data collected as part of the ALTIBRAIN randomized controlled trial (ClinicalTrials.gov: NCT06121206), involving cognitive tests and diffusion-weighted MRI.

Time Range

Measurements taken at baseline and 1 month after treatment completion (week 8).

Freshness

Data reflects a study published in April 2026.

Geography

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