ACLR Patient Clinical Data on Muscle Atrophy Risk Factors

Hanyi Wang's 2026 study provides clinical data from 26 ACLR patients, analyzing prognostic factors for quadriceps atrophy. The research correlates preoperative muscle fat infiltration, C-reactive protein levels, and meniscus repair with postoperative muscle changes. Single-cell RNA sequencing data on immobilized muscle cell composition and intercellular communication is included.

Use Cases

• Correlate preoperative muscle fat infiltration and C-reactive protein levels with quadriceps circumference changes post-ACLR.
• Analyze single-cell RNA sequencing data to examine cell composition shifts in immobilized muscle, focusing on MuSCs and FAPs proportions.
• Investigate ligand-receptor interactions and intercellular communication networks in immobilized muscle using CellChat analysis.
• Evaluate ferroptosis regulatory gene expression (pro- and anti-ferroptotic genes) in fibro/adipogenic progenitors under immobilization conditions.

Strengths

• Clinical data is derived from a specific cohort of 26 ACLR patients.
• Includes multi-modal data combining patient clinical characteristics with single-cell RNA sequencing results.
• Data supports analysis of specific biological mechanisms like ferroptosis suppression in FAPs.

Limitations

• Small sample size of 26 patients limits statistical power and generalizability of clinical findings.
• Dataset scope is limited to a single study's methodology and patient cohort.
• Primary data is embedded within a 478.4 KB DOCX document, requiring extraction for computational analysis.

Provenance

Source

Hanyi Wang via figshare.

Collection Method

Clinical correlation analysis and single-cell RNA sequencing performed on a cohort of ACLR patients.

Freshness

Last updated in March 2026.