Experimental Data on Salmonella Choleraesuis Inhibition by a Chinese Herbal Formula

Hua Chang's research article details the screening and testing of a Chinese herbal formula against Salmonella Choleraesuis in pigs. The study reports in-vitro Minimum Inhibitory and Bactericidal Concentrations (MIC of 15.625 mg/mL, MBC of 31.25 mg/mL) and in-vivo results from a mouse model showing a 66.7% protection rate. The data was uploaded to figshare in April 2026 under a CC-BY-4.0 license.

Use Cases

• Analyzing the efficacy of multi-herb combinations based on reported MIC/MBC values and orthogonal test results.
• Studying bacterial membrane damage mechanisms based on features like extracellular potassium ion concentration and transmission electron microscopy analyses.
• Investigating virulence gene inhibition based on the downregulation of type III secretion system (T3SS) genes (sipA/B/C, invA/F, etc.).
• Modeling immune modulation effects based on reported changes in sIgA levels and inflammatory factors (TNF-α, IL-1β, IL 6).

Strengths

• Provides specific quantitative results, including MIC (15.625 mg/mL) and MBC (31.25 mg/mL) values.
• Describes a multi-faceted experimental methodology covering in-vitro assays, gene expression (RT-qPCR), and an in-vivo mouse model.
• Includes statistically significant results (p < 0.01) for gene expression and cytokine changes.

Limitations

• The primary data file is a 322.2 KB DOCX document; the underlying raw experimental data (e.g., columnar results) is not directly accessible.
• Row count and data structure are unknown, limiting immediate suitability for computational analysis.
• The dataset's small size (322.2 KB) indicates it is likely a research article summary rather than a large-scale data repository.

Provenance

Source

Hua Chang via figshare

Collection Method

Experimental research involving microbroth dilution assays, orthogonal tests, RT-qPCR, and a mouse diarrhea model.

Time Range

Experimental timeframe not specified; publication date is 2026.

Freshness

Last updated 2026-04-14 05:36:00

Geography

Not specified, but the research context is the pig breeding industry and Chinese herbal medicine.