Probiotic-Conditioned Microbiota from Preterm Infants in a Mouse Model

A figshare-hosted dataset from the PRIMAL trial, authored by Justine Smout and last updated in April 2026. It contains results from a study where germ-free mice were colonized with fecal microbiota from probiotic- or placebo-treated preterm infants. The data likely includes measurements of immune cell populations and bacterial clearance following pathogen challenge.

Use Cases

• Modeling the impact of probiotic-conditioned microbiota on innate immune cell populations based on the described experimental results.
• Investigating the correlation between microbial shifts and infection outcomes following enteropathogenic Escherichia coli challenge.
• Analyzing the vertical transmission and stability of human-derived microbial communities across mouse generations.

Strengths

• Data is associated with a controlled clinical trial (PRIMAL trial) involving preterm infants.
• Results are derived from a germ-free mouse model, providing a controlled experimental environment.
• Dataset is openly available under a CC-BY-4.0 license.

Limitations

• The dataset is small (675.3 KB), indicating limited scope and likely summary-level results.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for certain analyses.

Provenance

Source

Justice Smout via figshare.

Collection Method

Data likely generated from a microbiota-humanized mouse model experiment using samples from the PRIMAL trial.

Freshness

Last updated 2026-04-20 04:13:35; freshness should be verified.