Proenkephalin A 119–159 Biomarker Levels in 100 End-Stage Kidney Disease Patients

A prospective cohort study of 100 adult patients with end-stage kidney disease undergoing maintenance hemodialysis. Plasma Proenkephalin A 119–159 (PENK) levels were measured before and after a single dialysis session and analyzed for correlation with estimated glomerular filtration rate and other markers. The dataset, authored by Luobei Zhang and last updated in April 2026, presents findings on PENK's limited utility for evaluating residual kidney function and dialysis adequacy in this patient population.

Use Cases

• Analyze the correlation between Proenkephalin A 119–159 (PENK) and estimated glomerular filtration rate (eGFR) based on the baseline measurements.
• Evaluate the clearance of the PENK biomarker during hemodialysis based on pre- and post-session level comparisons.
• Investigate associations between PENK and other clinical markers like BUN, SCr, NT-proBNP, and LVEF mentioned in the study results.
• Model biomarker stability in end-stage kidney disease patients based on factors like residual urine output and dialysis vintage described in the study.

Strengths

• Includes data from 100 patients, providing a specific cohort size for analysis.
• Contains paired measurements of PENK levels before and after a hemodialysis session for clearance evaluation.
• Correlates PENK with multiple established clinical markers (e.g., eGFR, BUN, SCr, NT-proBNP, LVEF).
• Released under a permissive CC-BY-4.0 license, allowing for reuse and redistribution.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the underlying data is unknown, which may limit suitability assessment.
• Data may reflect single-center study bias inherent to the described prospective cohort design.

Provenance

Source

Luobei Zhang via figshare.

Collection Method

Single-center prospective cohort study; plasma PENK levels determined via double-antibody sandwich enzyme-linked immunosorbent assay.

Freshness

Last updated 2026-04-14 04:14:28; freshness should be verified.