SARS-CoV-2 Immune Response Profiles from 209 Young Adult Trial Participants

209 participants in the CoVPN 3006 vaccine trial provided blood samples for profiling T-cell receptor repertoires and antibody responses. The dataset captures immune changes from pre-exposure, post-vaccination, and post-breakthrough infection stages. It enables analysis of hybrid immunological exposures and their impact on antibody potency and T-cell breadth.

Use Cases

• Analyze correlations between antibody neutralization levels and T-cell receptor repertoire breadth across vaccination and infection stages.
• Model the impact of hybrid exposure order (vaccination after infection vs. infection after vaccination) on clinical outcomes like shedding duration and peak nasal viral load.
• Train classifiers to predict attenuated disease severity using immune response markers from post-vaccination breakthrough infections.
• Profile TCR repertoire expansions from frozen blood clot genomic DNA to identify infection- or vaccine-specific T-cell clones.

Strengths

• Data from 209 participants in a controlled clinical trial (CoVPN 3006).
• Includes matched measurements for both humoral (antibody) and cellular (TCR) immunity from the same blood samples.
• Longitudinal design with samples from pre-exposure, post-vaccination, and post-breakthrough infection time points.

Limitations

• Sample size is limited to 209 young adults, which may not generalize to other age groups or populations.
• Data is derived from a specific protocol for recovering TCRs from frozen blood clots, which may introduce technical biases compared to standard PBMC methods.
• The dataset is contained within a 1.4 MB PDF, indicating it is likely a summary or processed data table, not the raw sequencing or assay outputs.

Provenance

Source

Andrew Fiore-Gartland via figshare.

Collection Method

TCR sequencing and antibody measurement from blood samples of participants in the CoVPN 3006 COVID-19 vaccine trial.

Time Range

Covers pre-exposure, post-vaccination, and post-breakthrough infection periods (specific dates not provided).

Freshness

Last updated March 25, 2026.

Geography

Multi-center cohort; specific locations not provided.