Vitamin D Deficiency Associations in Hospitalized Alcohol-Related Liver Disease Patients

115 hospitalized patients with alcohol-related liver disease (ALD) were analyzed between 2021 and 2024. The study associates serum 25-hydroxyvitamin D levels with disease severity, survival, and complications like sarcopenia. Vitamin D deficiency, present in 35.7% of patients, was an independent predictor of mortality and greater disease severity.

Use Cases

• Analyze the association between serum 25-hydroxyvitamin D levels and clinical outcomes like alcoholic hepatitis, cirrhosis, and ascites.
• Use vitamin D deficiency status as a feature in survival models predicting mortality, as validated by Kaplan-Meier and Cox regression analyses.
• Evaluate the diagnostic performance of serum 25(OH)D for predicting sarcopenia and spontaneous bacterial peritonitis using ROC curve analysis.
• Investigate the relationship between vitamin D status and composite severity scores like Model for End-Stage Liver Disease (MELD) and Maddrey discriminant function.

Strengths

• Clinical data from 115 hospitalized patients provides a focused cohort for analysis.
• Study includes multiple validated clinical endpoints: disease severity, survival, and specific complications (sarcopenia, SBP).
• Statistical analysis employs multivariable models (logistic and Cox regression) to identify independent predictors.

Limitations

• Small sample size of 115 patients limits statistical power and generalizability of findings.
• Retrospective study design and short follow-up period, as noted by the authors, introduce potential for bias.
• Limited event numbers for outcomes like mortality may affect the robustness of hazard ratio estimates.

Provenance

Source

Retrospective clinical study authored by Qiufeng He, shared via figshare.

Collection Method

Retrospective analysis of hospitalized patients with ALD; statistical methods included Spearman’s correlation, regression, survival, and ROC analysis.

Time Range

Patient data collected between 2021 and 2024.

Freshness

Data covers patients from 2021 to 2024, with the record last updated in March 2026.