Pediatric Kidney Transplant Outcomes with Banff Activity and Chronicity Indices

This single-center retrospective study includes 535 pediatric kidney transplant recipients from 2015 to 2025. It analyzes the prognostic impact of the Banff Activity Index (AI) and Chronicity Index (CI) on long-term graft function, with 98 recipients experiencing 126 rejection episodes.

Use Cases

• Identify risk factors for rejection using variables like HLA-DR mismatch, previous transplantation, and preformed donor-specific antibodies (pfDSA).
• Analyze the association between Banff Activity Index (AI) scores and short-term estimated glomerular filtration rate (eGFR) decline at diagnosis.
• Evaluate the link between high Chronicity Index (CI) scores (≥ 4) and long-term eGFR outcomes at 3 years post-rejection.
• Investigate predictors of high CI at first biopsy, such as donation after circulatory death (DCD) and biopsy timing ≥ 3 years post-transplantation.
• Compare histological activity and chronicity, measured by AI and CI, across different rejection phenotypes like mixed rejection.

Strengths

• Includes 535 pediatric kidney transplant recipients, a substantial cohort for a single-center study.
• Contains longitudinal eGFR trajectory data for evaluating long-term graft functional outcomes.
• Analyzes specific, quantifiable histological indices (Banff AI and CI) linked to clinical outcomes.

Limitations

• Data is from a single center, which may limit generalizability to other populations or healthcare settings.
• The primary data format is a DOCX document (879.8 KB), which is not a structured, machine-readable tabular format.
• The study period (2015-2025) includes future years, suggesting the data may be partially projected or incomplete.

Provenance

Source

figshare, authored by Jianming Li.

Collection Method

Single-center retrospective study.

Time Range

Transplantations between 2015 and 2025.

Freshness

Last updated 2026-03-20.