Statin Use and Colorectal Cancer Prognosis: A Systematic Review and Meta-Analysis

A systematic review and meta-analysis of 25 observational studies involving 179,979 colorectal cancer patients, assessing the association between statin use and survival outcomes. The study, authored by Gang Li and published on figshare in March 2026, pools hazard ratios for all-cause and cancer-specific mortality. It includes studies from database inception until October 31, 2025, and employs a random-effects model for pooled analyses.

Use Cases

• Conducting a meta-analysis on drug effects based on pooled hazard ratios for mortality outcomes.
• Investigating the prognostic impact of medication timing based on pre-diagnosis and post-diagnosis use categories.
• Validating observational study findings in oncology based on a synthesis of 25 included studies.
• Assessing study quality in systematic reviews based on the application of the Newcastle-Ottawa Scale.

Strengths

• Analysis is based on a large patient cohort of 179,979 individuals from 25 studies.
• Provides specific pooled hazard ratios with 95% confidence intervals for multiple mortality endpoints (e.g., ACM HR: 0.80; 95%CI: 0.74-0.86).
• Distinguishes between pre-diagnosis and post-diagnosis statin use, allowing for temporal analysis of effects.
• Study protocol was pre-registered (INPLASY2025110064), which suggests structured methodology.

Limitations

• The dataset is a single 11.0 KB document, representing a summary publication rather than raw study data.
• Row and column-level data from the original studies are unavailable, limiting secondary analysis.
• The findings are based on observational studies, which may be subject to confounding factors not addressed in the meta-analysis.

Provenance

Source

Gang Li via figshare.

Collection Method

Systematic review and meta-analysis of studies from PubMed, Embase, Cochrane Library, and Web of Science.

Time Range

Studies from database inception until October 31, 2025.

Freshness

Last updated 2026-03-18 05:21:14; includes literature up to October 31, 2025.