Prognostic Value of Emotional Distress in Advanced Lung Cancer: A Meta-Analysis

A systematic review and meta-analysis by Jia-jia Lin, published on figshare in 2026, evaluating the association between emotional distress and treatment outcomes in advanced non-small cell lung cancer. The analysis includes eight studies involving 911 patients who received various anti-tumor therapies, including chemotherapy, radiotherapy, targeted therapy, and immune checkpoint inhibitors. It reports hazard ratios for overall survival and progression-free survival, and odds ratios for objective response rate.

Use Cases

• Training predictive models for patient survival based on emotional distress markers mentioned in the description
• Conducting secondary meta-analyses on psychosocial oncology using the reported hazard and odds ratios
• Informing clinical trial design for interventions targeting emotional distress in cancer patients
• Benchmarking prognostic models against established associations between distress and clinical outcomes like OS and PFS

Strengths

• Includes data from eight distinct cohort studies, providing a multi-study perspective.
• Reports specific statistical results, including an overall survival HR of 1.85 (95% CI: 1.50–2.28).
• Conducted subgroup analyses by treatment type (e.g., ICI-based, chemotherapy).
• Performed sensitivity analysis supporting the stability of the primary findings.

Limitations

• The dataset is a 286.1 KB DOCX document; the underlying raw study data is not provided.
• The certainty of evidence was rated as low for OS and ORR, and very low for PFS.
• Row count and column-level documentation for any underlying data are unknown.

Provenance

Source

figshare, author Jia-jia Lin.

Collection Method

Systematic review and meta-analysis of eligible cohort studies.

Freshness

Last updated 2026-05-20 05:56:03.