Longitudinal Parkinson's Disease Progression Data for GBA1 Variant Carriers

Anne-Marie Hanff's 2026 study provides longitudinal data from 726 individuals with typical Parkinson's disease, including 22 carriers of severe GBA1 variants and 47 carriers of PD-risk variants. It analyzes symptom progression using linear mixed models to assess cognitive decline and non-motor symptoms.

Use Cases

• Model cognitive decline progression in carriers of severe versus PD-risk GBA1 variants using longitudinal data.
• Analyze worsening of apathy, sleep quality, and tremor symptoms associated with PD-risk variant carrier status.
• Assess non-motor symptom progression measured by MDS-UPDRS I scores across different GBA1 variant groups.

Strengths

• Includes data from 726 individuals with typical Parkinson's disease.
• Specifically compares 22 carriers of severe GBA1 variants and 47 carriers of PD-risk variants.
• Longitudinal design tracks symptom progression over time.

Limitations

• Small sample sizes for key subgroups (22 severe, 47 risk variant carriers) limit statistical power.
• Findings were not significant after Bonferroni correction, requiring cautious interpretation.
• Data is contained in a 269.2 KB DOCX file, indicating limited raw data scope.

Provenance

Source

Anne-Marie Hanff via figshare.

Collection Method

Longitudinal mixed model analysis of clinical cohort data.

Time Range

null

Freshness

Last updated March 2026.

Geography

null