Proteasomal Inhibition Effects on Microvascular Endothelial and Immune Cells
by Prajakta Sawant·Updated 19d ago
1.5 MB1files
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Description
A research document from figshare, authored by Prajakta Sawant and last updated in May 2026, details a study on the acute adverse effects of chemotherapeutic proteasomal inhibitors Bortezomib and Carfilzomib. The work investigates cytotoxicity, stress pathway activation, and barrier function loss in human pulmonary microvascular endothelial cells, peripheral blood mononuclear cells, and multiple myeloma cells. It models the synergistic impact of the inflammatory cytokine TNF present in the patient microenvironment.
Use Cases
Analyzing drug-induced cytotoxicity patterns based on the comparison of Bortezomib and Carfilzomib effects described in the study.
Modeling stress pathway activation (proteotoxic, ER stress, ROS) in endothelial cells based on the described experimental outcomes.
Investigating the synergistic role of inflammatory cytokines like TNF in exacerbating drug-mediated endothelial damage as outlined in the findings.
Strengths
The dataset is associated with a specific, detailed research study comparing two proteasomal inhibitors at defined concentrations (e.g., 100 nM BTZ, 250 nM CFZ).
It includes experimental observations on multiple cell types (HPMECs, PBMCs, MM1.S cells) and measures several biological endpoints (cytotoxicity, caspase activation, barrier function).
The data is shared under a permissive CC-BY-4.0 license, facilitating reuse.
Limitations
The primary data format is a 1.5 MB DOCX file, which likely contains a manuscript or report rather than structured, machine-readable data tables.
Column-level documentation and sample data are unavailable, making direct computational analysis difficult without manual extraction.
Row count is unknown, which may limit suitability assessment for quantitative modeling.
Provenance
Source
figshare
Collection Method
Likely contains experimental laboratory data from in vitro cell culture studies as described.
Freshness
Last updated 2026-05-19 05:29:12; freshness should be verified.
The dataset is a 1.5 MB DOCX document; users will need appropriate software to open and may need to manually extract any underlying numerical or tabular data from the text.