Protective Effect of Carica Papaya Leaf Extract Against Lead Toxicity in Wistar Rats

A 30-day experimental study by Richard Haakonde, published on figshare in 2026, evaluating the protective effect of Carica papaya leaf ethanolic extract against lead-induced toxicity in Wistar rats. The dataset likely contains results from 30 animals across 6 treatment groups, measuring body weight changes, lead concentrations in blood and tissues, and oxidative stress markers. The findings suggest the extract may mitigate lead toxicity through chelation and antioxidant activities.

Use Cases

• Modeling dose-response relationships for plant extract efficacy based on the described treatment groups and doses.
• Analyzing correlations between lead tissue accumulation and oxidative stress markers like malondialdehyde levels.
• Comparing the protective effects of different phytochemical extracts against heavy metal toxicity based on the described methodology.

Strengths

• Study design includes 30 animals across 6 treatment groups with a 30-day exposure period.
• Measures multiple endpoints: body weight, lead concentration in four tissues, and a key oxidative stress biomarker.
• Data is openly shared under a CC-BY-4.0 license, facilitating reuse and verification.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The primary data file is a DOCX document, which may require extraction and structuring for computational analysis.

Provenance

Source

Richard Haakonde via figshare

Collection Method

Experimental study on Wistar rats exposed to lead acetate and treated with Carica papaya leaf extract.

Time Range

Experimental period of 30 days; publication date 2026.

Freshness

Last updated 2026-04-09 22:02:19; freshness should be verified.

Geography

Laboratory study; geographic origin of the research is unspecified.