Meta-Analysis of Salidroside Effects on Rodent NAFLD Models

A systematic review and meta-analysis synthesizes results from 12 eligible animal studies on salidroside treatment for non-alcoholic fatty liver disease. The analysis, conducted by Shuai Li and published in 2026, evaluates therapeutic effects on outcomes like hepatic triglycerides, liver enzymes, and inflammatory markers. It provides statistical measures including standardized mean differences for numerous biochemical and histological indicators.

Use Cases

• Analyze dose-response relationships for salidroside using reported SMD values for hepatic TG and serum TC across different dosage groups.
• Compare treatment efficacy between species by examining the NAS score SMD results, which indicate rats showed a better therapeutic effect than mice.
• Model the impact of treatment duration on liver function by correlating the SMD values for serum ALT and AST with the reported more pronounced effect for durations ≤4 weeks.
• Investigate the relationship between oxidative stress markers by using the reported SMD values for MDA, GSH, and SOD from the included studies.
• Assess publication bias and result robustness using the sensitivity analysis and funnel plot findings described in the results section.

Strengths

• Analysis is based on a systematic search of 8 major scientific databases up to June 2025.
• Reports standardized mean difference (SMD) results for over 20 distinct outcome indicators from the meta-analysis.
• Includes a quality assessment of the 12 included studies using the SYRCLE bias risk tool.

Limitations

• The dataset is very small, consisting of a single 42.1 KB document summarizing the analysis, not the underlying study data.
• Findings are derived from rodent models, limiting direct applicability to human clinical contexts as noted in the conclusion.
• The authors report a certain degree of publication bias was present among the included studies.

Provenance

Source

figshare, authored by Shuai Li.

Collection Method

Systematic review and meta-analysis of 12 previously published animal studies identified from database searches.

Time Range

Literature search covered studies up to June 2025; analysis document dated 2026.

Freshness

Document last updated in April 2026, based on a literature search up to June 2025.