Proteomic Signatures of Post-Vaccination Syndrome in 30 Individuals

Plasma proteomic analysis compares 14 individuals with Post-Vaccination/Post-Infection Syndrome (PV/PIS) to 16 healthy controls. The study identifies alterations in coagulation factors, acute phase proteins, and immune response modulators using liquid-chromatography-mass spectrometry. It was authored by Maxine Waters and published in March 2026.

Use Cases

• Identify protein biomarkers like serum amyloid A1 and A2 for distinguishing PV/PIS from healthy controls.
• Analyze dysregulation patterns in coagulation factors X and XI to study coagulopathy in post-vaccination syndromes.
• Compare proteomic signatures of attractin and other immune modulators between PV/PIS and historical Long COVID cohorts.

Strengths

• Direct comparison of 14 case and 16 control samples provides a defined cohort.
• Proteomic analysis covers specific proteins linked to coagulation, acute phase response, and immune regulation.
• Findings are contextualized against prior Long COVID proteomics, highlighting distinct signatures.

Limitations

• Small sample size of 30 total individuals limits statistical power and generalizability.
• Data is presented in a PDF report (1.2 MB), not in a structured, machine-readable tabular format.
• Cohort definition relies on self-reported persistent symptoms without confirmed prior infection history.

Provenance

Source

figshare

Collection Method

Liquid-chromatography-mass spectrometry analysis of digested microclot deposits from platelet-poor plasma.

Time Range

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Freshness

Last updated March 2026.

Geography

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