Qijia Rougan Formula: Anti-Fibrotic Effects in Stage F3 Mouse Model

436.2 KB of research documentation details the anti-fibrotic effects of the Qijia Rougan Formula (QRF) in a mouse model of Stage F3 liver fibrosis. Xin Ding authored this study, which employs molecular docking, transcriptomic analysis, and in vitro macrophage assays to investigate mechanisms. The findings, last updated in May 2026, suggest QRF inhibits NLRP3-mediated pyroptosis and promotes macrophage polarization.

Use Cases

• Analyze transcriptomic profiles of differentially expressed genes (DEGs) from the mouse model
• Study molecular docking predictions for ligand-protein interactions between QRF and NLRP3 pathway components
• Investigate macrophage polarization dynamics from M1 to M2 phenotype based on in vitro assays
• Validate anti-pyroptotic effects via NLRP3-specific agonist rescue experiments

Strengths

• The study employs a multi-tiered investigative strategy including molecular docking, transcriptomics, and in vitro functional assays
• A functional rescue experiment using the NLRP3 agonist Nigericin establishes causality for the mechanism
• The documentation is licensed under CC-BY-4.0, allowing for open reuse

Limitations

• The dataset is a 436.2 KB DOCX file, likely containing a research paper rather than structured data tables
• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment

Provenance

Source

figshare

Collection Method

Research study involving C57BL/6 mouse models, molecular docking, transcriptomic profiling, and in vitro macrophage experiments.

Freshness

Last updated 2026-05-05 04:10:22; freshness should be verified