Planarian Behavioral Screening Data for Organophosphorus Pesticide Mixtures

Experimental data from a high-throughput screening of 21 binary mixtures of 7 organophosphorus pesticides on Dugesia japonica planarians. The dataset includes 22 readouts quantifying lethality, stickiness, and behavior at days 7 and 12 post-exposure for adult and regenerating organisms. It was created by Danielle Ireland and published on figshare under a CC-BY-4.0 license in March 2026.

Use Cases

• Modeling mixture interactions (additivity, synergism, antagonism) based on behavioral and lethality readouts.
• Investigating developmental neurotoxicity by comparing effects on adult vs. regenerating planarians.
• Correlating behavioral outcomes like stickiness with biochemical endpoints such as acetylcholinesterase inhibition.
• Testing predictions of concentration addition models like the Loewe model against experimental mixture data.

Strengths

• Includes 22 distinct readouts per experiment, covering lethality, stickiness, and multiple behaviors.
• Tests 21 specific binary mixtures of 7 named organophosphorus pesticides across a concentration range.
• Compares results across two developmental stages (adult and regenerating planarians).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (707.1 KB), indicating a limited experimental scope.

Provenance

Source

figshare, author Danielle Ireland.

Collection Method

Data generated via an automated high-throughput screening platform on planarians exposed to pesticide mixtures.

Freshness

Last updated 2026-03-25 22:02:14; freshness should be verified.