Brexpiprazole Continuation and Outcomes in Inpatient Schizophrenia Treatment, 2018-2024

Yuki Noriyama's dataset describes a retrospective observational study of 67 inpatients with DSM-5 schizophrenia treated with brexpiprazole at a Japanese university hospital between June 2018 and July 2024. The data includes 8-week continuation rates, reasons for discontinuation, and longitudinal changes in Clinical Global Impressions–Severity (CGI-S) and Brief Psychiatric Rating Scale (BPRS) scores. The dataset was last updated on 2026-05-05 and is shared under a CC-BY-4.0 license.

Use Cases

• Analyze factors associated with antipsychotic continuation based on patient demographics and treatment history mentioned in the description.
• Model longitudinal symptom severity changes based on Clinical Global Impressions–Severity (CGI-S) and Brief Psychiatric Rating Scale (BPRS) scores over an 8-week period.
• Investigate reasons for medication discontinuation based on categories like adverse events, insufficient efficacy, and patient preference.
• Study the impact of concomitant psychotropic medication use on treatment outcomes as an exploratory analysis variable.

Strengths

• Includes data from 67 patients, providing a specific cohort size for analysis.
• Contains longitudinal clinical outcome measures (CGI-S and BPRS scores) at weeks 0, 4, and 8.
• Documents specific continuation rates (53.7% at week 8) and reasons for discontinuation with patient counts.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data reflects a single-center, retrospective design from Japan, which may limit generalizability.

Provenance

Source

figshare, author Yuki Noriyama

Collection Method

Retrospective observational study using electronic medical records from a university hospital.

Time Range

June 2018 to July 2024

Freshness

Last updated 2026-05-05 08:52:12; freshness should be verified.

Geography

Japan (single university hospital)