Calreticulin and ERp57 Reduction with Age: ER Stress Roles in Cell Viability and Lifespan

Gregor Burdeos published a research data sheet on figshare in March 2026. The document describes a study investigating the age-related reduction of endoplasmic reticulum proteins Calreticulin and ERp57 in mouse tissues and C. elegans. The work links these reductions to increased ER stress, decreased cell viability, and shortened organismal lifespan.

Use Cases

• Study the correlation between chaperone protein levels and aging based on protein expression data from mouse tissues.
• Investigate the impact of ER protein knockdown on cell viability and apoptosis based on experiments in N2a cells.
• Model the relationship between ER stress and organismal lifespan based on C. elegans assays.
• Analyze protein aggregation under stress conditions based on experimental results described in the document.

Strengths

• Data is associated with a specific, peer-reviewed research study on a defined biological mechanism.
• The dataset is licensed under CC-BY-4.0, allowing for broad reuse and sharing.
• Platform tags provide clear domain classification for discovery.

Limitations

• The dataset is a 1.5 MB DOCX file, which is a small document and not a structured data table.
• Row count and column-level documentation are absent; data semantics must be inferred from the text.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

Gregor Burdeos via figshare.

Collection Method

Experimental data from analysis of mouse brain/liver tissues, C. elegans lifespan assays, and N2a cell culture experiments.

Freshness

Last updated 2026-03-17 13:05:05; freshness should be verified.