Renal Involvement in Hypereosinophilic Syndrome: A Systematic Review of 42 Cases

Qi-shun Wu's systematic review characterizes kidney disease in hypereosinophilic syndrome (HES). The analysis synthesizes findings from 37 studies covering 42 cases, with pathology results graded for certainty of evidence. The dataset was last updated on April 23, 2026, and is available under a CC-BY-4.0 license.

Use Cases

• Analyze the clinicopathologic spectrum of HES-related kidney disease based on the reported prevalence of acute eosinophilic interstitial nephritis (54.8%) and other lesions.
• Investigate diagnostic differentiation from IgG4-related kidney disease based on reported IgG4+/IgG+ ratio observations.
• Review therapeutic evidence for HES-related kidney disease based on the reported outcomes of 14 cases treated with anti-IL-5/IL-5Rα biologics.

Strengths

• Analysis is based on a systematic review of 2,247 records following a PROSPERO-registered protocol.
• Includes specific quantitative findings, such as 23 out of 42 cases presenting with acute eosinophilic interstitial nephritis.
• Provides domain-specific GRADE assessments for the certainty of evidence on pathology, diagnosis, and therapy.

Limitations

• The dataset is a 211.0 KB PDF document; the underlying structured data (e.g., columns, rows) is unavailable.
• Evidence certainty is rated as low to very low due to selection bias, inconsistency, and publication bias as noted in the review.
• Row count and column-level documentation are unknown, which limits suitability assessment for computational analysis.

Provenance

Source

Qi-shun Wu via figshare

Collection Method

Systematic review with narrative synthesis of six databases from inception to February 27, 2026.

Time Range

Studies from database inception to February 2026

Freshness

Last updated 2026-04-23 05:26:55