Thrombin-Coated Controllable Coil: Research on Preventing Aortic Aneurysm Complications

A research document by E. Erdemutu details the development and testing of a novel vascular embolization material. The study characterizes the Thrombin-Coated Controllable Coil's physicochemical properties and evaluates its performance in preventing Type II Endoleak using in vitro assays and a Bama minipig model. The document was last updated on 2026-06-01.

Use Cases

• Benchmarking new embolic materials based on physicochemical properties like drug loading and solubility time
• Studying cellular responses to biomaterials based on in vitro effects on vascular smooth muscle and endothelial cells
• Evaluating in vivo efficacy for preventing Type II Endoleak based on results from an animal aneurysm model
• Investigating molecular mechanisms of thrombosis based on transcriptomic analysis of differentially expressed genes

Strengths

• The document provides specific quantitative results, including an average drug loading of 0.0066 g and a water solubility time of 1080 seconds
• Research methodology is detailed, covering in vitro cell assays, dynamic coagulation tests, and an in vivo animal model
• Transcriptomic analysis identified 161 differentially expressed genes, offering mechanistic insights

Limitations

• The dataset is a single 621.3 KB DOCX file, which is a very small-scale research document rather than a structured data collection
• Row count and column-level documentation are absent; data must be manually extracted from the text
• The primary content is a research paper; structured, machine-readable data tables are not provided

Provenance

Source

E. Erdemutu via figshare

Collection Method

Experimental research involving material synthesis, in vitro assays, and an animal model study.

Freshness

Last updated 2026-06-01 05:23:06