Rat Study Data on 2-Methoxyestradiol Effects After Subarachnoid Hemorrhage

A 29.6 MB dataset from a retracted study by Qiang Hu, last updated in April 2026. The data likely contains measurements from a rat model of subarachnoid hemorrhage, including neurological scores, brain water content, and biomarker expression levels. The study investigated the effects of 2-Methoxyestradiol on neuroinflammation and brain edema.

Use Cases

• Analyze the relationship between biomarker levels (e.g., IL-1β, TNF-α) and neurological scores based on the described experimental results.
• Model the effects of drug intervention (2-ME) on brain water content and blood-brain barrier permeability based on the described measurements.
• Investigate correlations between microglial activation, cell apoptosis, and tight junction protein disruption (ZO 1, occludin) as described in the study.

Strengths

• Data is associated with a detailed experimental protocol described in the input, including specific measurement methods like immunofluorescence and western blotting.
• The dataset is licensed under CC-BY-4.0, allowing for open sharing and reuse.
• File size is 29.6 MB, indicating a manageable download and storage footprint.

Limitations

• The dataset is marked as RETRACTED, which may indicate underlying issues with the research findings.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for specific analytical tasks.

Provenance

Source

figshare

Collection Method

Data generated from a laboratory study using an endovascular puncture rat model of subarachnoid hemorrhage.

Time Range

Measurements were taken 24 hours after surgery, as per the described methods.

Freshness

Last updated 2026-04-27 13:30:28; freshness should be verified.

Geography

Laboratory study; geographic origin of the data is not specified.