Review of Macrophage Immunometabolism in Gouty Arthritis and Nanotherapeutic Strategies

A scholarly review paper systematically dissects metabolic shifts in gouty arthritis, focusing on macrophage reprogramming from oxidative phosphorylation to glycolysis. Authored by Feng Xiao and uploaded to figshare in April 2026, the document explores the "metabolic-epigenetic" axis and emerging nanotherapeutic strategies targeting metabolic checkpoints. The file is a 578 KB PDF licensed under CC-BY-4.0.

Use Cases

• Analyze metabolic reprogramming in macrophages based on the description of the Warburg effect and TCA cycle breakpoints
• Review nanotherapeutic strategies based on the summary of nanoenzymes and biomimetic carriers
• Study metabolite-mediated crosstalk based on the emphasis on the "metabolic-epigenetic" axis
• Investigate macrophage polarization based on the discussion of repolarizing M1 to M2 phenotypes

Strengths

• The review is the first to systematically integrate macrophage metabolism, epigenetic crosstalk, and nanotargeting for gout, according to the description
• The document is openly licensed under CC-BY-4.0, allowing for reuse
• The file is a PDF of 578 KB, a manageable size for download and review

Limitations

• The dataset is a single PDF review paper, not a collection of structured data records
• Row count and column-level documentation are absent, limiting suitability for direct ML use
• The content is a review of existing knowledge, not primary experimental or observational data

Provenance

Source

figshare

Freshness

Last updated 2026-04-29 05:41:35