RBscore: Three-Gene Ribosome Biogenesis Score for Bladder Cancer Prognosis

A three-gene ribosome biogenesis-related score (RBscore) derived from tumor transcriptomes in the TCGA-BLCA cohort and validated in GSE13507. The dataset, authored by Guangyue Luo and last updated in April 2026, links the RBscore to survival stratification, immune contexture, and pharmacogenomic associations in bladder cancer. The underlying data is likely tabular, containing gene expression and clinical variables.

Use Cases

• Predicting overall survival in bladder cancer patients based on the three-gene RBscore.
• Analyzing associations between ribosome biogenesis programs and tumor immune microenvironment features.
• Identifying candidate therapeutic compounds via pharmacogenomic associations supported by molecular docking.
• Investigating the relationship between RBscore groups and somatic mutation profiles like TP53.

Strengths

• Derived from survival-annotated tumor transcriptomes in the TCGA-BLCA cohort, a recognized cancer genomics resource.
• Externally validated in an independent dataset (GSE13507).
• Integrates multiple analysis layers including pathway enrichment, immune features, and pharmacogenomics.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The primary file is a 1.7 MB DOCX document, which may require extraction of underlying data.

Provenance

Source

figshare

Collection Method

Analysis of survival-annotated tumor transcriptomes from TCGA-BLCA and GSE13507.

Time Range

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Freshness

Last updated 2026-04-16 05:16:32.

Geography

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